The transmission disequilibrium test (TDT) was proposed by Spielman, McGinnis and Ewens (1993)[1] as

by | Aug 30, 2021 | Essay (any type) | 0 comments

The transmission disequilibrium test (TDT) was proposed by Spielman, McGinnis and Ewens (1993)[1] as a family-based association test for the presence of genetic linkage between a genetic marker and a trait. It is an application of McNemar’s test.

Read the paper “Transmission Test for Linkage Disequilibrium: The Insulin Gene Region and Insulin-dependent Diabetes Mellitus (IDDM)” by Spielman et al. published on American Journal of Human Genetics (AJHG) and write one page summarizing what you learned, you can cite some sentences from the paper that clarify some of your understandings in concepts we have been discussing in the class, such as linkage and linkage disequilibrium, samples used to examine these etc.

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